Border Collie Collapse Syndrome*

Border Collie Collapse Syndrome is an exercise induced collapse seen in several breeds including Shetland Sheepdogs. It is not the same as Exercise Induced Collapse of Labrador Retrievers or the result of heat stroke. “Affected dogs are normal at rest and seem healthy. Typical collapse episodes begin 5 – 15 min after onset of exercise and include disorientation, dull mentation or loss of focus; swaying, staggering and falling to the side; exaggerated lifting of each limb while walking and a choppy gait; scuffing of the rear and/or forelegs, and crossing of the legs when turning.”

Researchers at the College of Veterinary Medicine, University of Minnesota are studying the problem. Even though the web page describing the syndrome and study primarily talks about Border Collies, participation of Sheltie owners is welcome and encouraged. There is strong evidence of the problem being a genetic trait, but it is likely to be a more complex one rather than a simple one-locus Mendelian trait. Videos of affected dogs, additional information about the problem and information needed to participate in the study may be found at the following website:

*1st posted in 2014. The research group is still accepting DNA samples from affected dogs.


Study on Inheritance of Legg-Calve-Perthes Disease*

Legg-Calve-Perthes Disease (LCP) is a disorder of hip joint conformation occurring in both humans and dogs. In dogs, it is most often seen in the miniature and small breed dogs. Shetland Sheepdogs are on the list of affected breeds. The age on onset of clinical signs (lameness) occurs from 4 – 12 months of age with 9 months of age being more common.

Dr. Leigh Anne Clark, of the Clark Canine Genetics Research Laboratory, Clemson University, is studying the inheritance of LCP in Shetland Sheepdogs and DNA samples from affected dogs are needed.

If you have an affected dog and are willing to participate, please contact Dr. Clark at:

Leigh Anne Clark, Ph.D.
057 Life Sciences Facility
190 Collings St.
Clemson University
Clemson, SC 29634

More information about LCP can be found on the OFA website at:


*Posted May 2017.